SIAH1

SIAH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A25, 4C9Z, 4CA1, 4I7B, 4I7C, 4I7D, 4X3G
Identifiers
Aliases	SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1, BURHAS
External IDs	OMIM: 602212; MGI: 108064; HomoloGene: 20654; GeneCards: SIAH1; OMA:SIAH1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	48,448,402 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	87,472,562 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; ganglionic eminence; ; amniotic fluid; ; skin of hip; ; placenta; ; germinal epithelium; ; gonad; ; retinal pigment epithelium; ; skin of thigh;
	Top expressed in
	secondary oocyte; ; medial ganglionic eminence; ; Rostral migratory stream; ; primary oocyte; ; barrel cortex; ; hair follicle; ; spermatocyte; ; retinal pigment epithelium; ; sexually immature organism; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; identical protein binding; ubiquitin protein ligase activity; protein binding; zinc ion binding; transferase activity; ubiquitin-protein transferase activity; protein C-terminus binding; ubiquitin conjugating enzyme binding;
Cellular component	beta-catenin destruction complex; cytoplasm; nucleus; early endosome; cytosol; plasma membrane;
Biological process	cell cycle; spermatogenesis; axon guidance; multicellular organism development; anatomical structure morphogenesis; positive regulation of intrinsic apoptotic signaling pathway; apoptotic process; protein catabolic process; positive regulation of apoptotic process; nervous system development; protein ubiquitination; cell differentiation; protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein destabilization; neuron apoptotic process; ubiquitin-dependent protein catabolic process; negative regulation of netrin-activated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6477
	20437
	ENSG00000196470
	ENSMUSG00000036840
	Q8IUQ4
	P61092
	NM_001006610; NM_003031; NM_001006611
	NM_009172
	NP_001006611; NP_003022
	NP_033198
	Wikidata
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