SIPA1

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.^[5][6]

AliasesSIPA1, SPA1, signal-induced proliferation-associated 1

External IDsOMIM: 602180; MGI: 107576; HomoloGene: 7940; GeneCards: SIPA1; OMA:SIPA1 - orthologs

Chr.Chromosome 11 (human)^[1]

End65,650,918 bp^[1]

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SIPA1
Identifiers
Aliases	SIPA1, SPA1, signal-induced proliferation-associated 1
External IDs	OMIM: 602180; MGI: 107576; HomoloGene: 7940; GeneCards: SIPA1; OMA:SIPA1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,638,101 bp[1] End 65,650,918 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 5,701,213 bp[2] End 5,713,735 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen apex of heart upper lobe of left lung sural nerve right lung monocyte blood right lobe of liver left uterine tube Top expressed in granulocyte mesenteric lymph nodes yolk sac spleen thymus blood internal carotid artery external carotid artery tibiofemoral joint left lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity protein C-terminus binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol transport vesicle membrane endomembrane system nucleus protein-containing complex Biological process negative regulation of cell adhesion negative regulation of cell cycle cellular response to water deprivation cell population proliferation intracellular signal transduction regulation of small GTPase mediated signal transduction cytoskeleton organization negative regulation of cell growth signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6494 20469 Ensembl ENSG00000213445 ENSMUSG00000056917 UniProt Q96FS4 P46062 RefSeq (mRNA) NM_006747 NM_153253 NM_001164480 NM_001164481 NM_001164482 NM_001164568 NM_011379 RefSeq (protein) NP_006738 NP_694985 n/a Location (UCSC) Chr 11: 65.64 – 65.65 Mb Chr 19: 5.7 – 5.71 Mb PubMed search [3] [4]
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The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.^[6]