SLAMF6

SLAMF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IF7
Identifiers
Aliases	SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDs	OMIM: 606446; MGI: 1353620; HomoloGene: 49945; GeneCards: SLAMF6; OMA:SLAMF6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,523,262 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,780,737 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; spleen; ; appendix; ; blood; ; bone marrow cell; ; superficial temporal artery; ; gallbladder; ; mucosa of transverse colon; ; rectum;
	Top expressed in
	thymus; ; spleen; ; lymph node; ; blood; ; mesenteric lymph nodes; ; gastrula; ; granulocyte; ; submandibular gland; ; subcutaneous adipose tissue; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane;
Biological process	natural killer cell proliferation; immune system process; positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; innate immune response; positive regulation of natural killer cell mediated cytotoxicity; adaptive immune response; T-helper 17 cell lineage commitment; regulation of immune response; natural killer cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	114836
	30925
	ENSG00000162739
	ENSMUSG00000015314
	Q96DU3
	Q9ET39
	NM_052931; NM_001184714; NM_001184715; NM_001184716
	NM_030710; NM_001347186; NM_001347187
	NP_001171643; NP_001171644; NP_001171645; NP_443163
	NP_001334115; NP_001334116; NP_109635
	Wikidata
View/Edit Human	View/Edit Mouse

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.^[5]^[6]

PDBOrtholog search: PDBe RCSB

AliasesSLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6

External IDsOMIM: 606446; MGI: 1353620; HomoloGene: 49945; GeneCards: SLAMF6; OMA:SLAMF6 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts Available structures, PDB ...

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The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

SLAMF6

References

Further reading

Related Articles

Related Articles

"NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease"

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"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

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"Signal peptide prediction based on analysis of experimentally verified cleavage sites"

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