SLC20A1

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.^[5][6]

AliasesSLC20A1, GLVR1, Glvr-1, PIT1, PiT-1, solute carrier family 20 member 1

External IDsOMIM: 137570; MGI: 108392; HomoloGene: 38049; GeneCards: SLC20A1; OMA:SLC20A1 - orthologs

Chr.Chromosome 2 (human)^[1]

End112,663,825 bp^[1]

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SLC20A1
Identifiers
Aliases	SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1, solute carrier family 20 member 1
External IDs	OMIM: 137570; MGI: 108392; HomoloGene: 38049; GeneCards: SLC20A1; OMA:SLC20A1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 112,645,939 bp[1] End 112,663,825 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 62.79 cM Start 129,040,684 bp[2] End 129,053,536 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon granulocyte cartilage tissue trachea retinal pigment epithelium mucosa of urinary bladder trabecular bone parietal pleura appendix mucosa of paranasal sinus Top expressed in pontine nuclei left colon medial vestibular nucleus facial motor nucleus lobe of cerebellum deep cerebellar nuclei cerebellar vermis fetal liver hematopoietic progenitor cell anterior horn of spinal cord dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium:phosphate symporter activity high-affinity inorganic phosphate:sodium symporter activity symporter activity signal transducer activity inorganic phosphate transmembrane transporter activity sodium:inorganic phosphate symporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process phosphate-containing compound metabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling phosphate ion transmembrane transport phosphate ion transport ion transport sodium ion transmembrane transport sodium ion transport signal transduction transmembrane transport sodium-dependent phosphate transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6574 20515 Ensembl ENSG00000144136 ENSMUSG00000027397 UniProt Q8WUM9 Q61609 RefSeq (mRNA) NM_005415 NM_001159593 NM_015747 NM_001355252 RefSeq (protein) NP_005406 NP_001153065 NP_056562 NP_001342181 Location (UCSC) Chr 2: 112.65 – 112.66 Mb Chr 2: 129.04 – 129.05 Mb PubMed search [3] [4]
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Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM]^[6]