SLC22A1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.[5][6]
Function
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[6]
It is also required for the uptake of metformin by cells.[7][8]