SLC22A11

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.^[3][4][5][6]

AliasesSLC22A11, OAT4, hOAT4, solute carrier family 22 member 11

External IDsOMIM: 607097; HomoloGene: 81863; GeneCards: SLC22A11; OMA:SLC22A11 - orthologs

Chr.Chromosome 11 (human)^[1]

End64,572,875 bp^[1]

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SLC22A11
Identifiers
Aliases	SLC22A11, OAT4, hOAT4, solute carrier family 22 member 11
External IDs	OMIM: 607097; HomoloGene: 81863; GeneCards: SLC22A11; OMA:SLC22A11 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,555,690 bp[1] End 64,572,875 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta kidney tubule metanephric glomerulus human kidney testicle corpus epididymis caput epididymis tail of epididymis renal medulla right adrenal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function organic anion transmembrane transporter activity protein binding inorganic anion exchanger activity transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity urate transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome apical plasma membrane external side of plasma membrane membrane Biological process sodium-independent organic anion transport ion transport urate metabolic process organic anion transport transmembrane transport inorganic anion transport urate transport organic acid transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55867 n/a Ensembl ENSG00000168065 n/a UniProt Q9NSA0 n/a RefSeq (mRNA) NM_001307985 NM_018484 n/a RefSeq (protein) NP_001294914 NP_060954 n/a Location (UCSC) Chr 11: 64.56 – 64.57 Mb n/a PubMed search [2] n/a
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The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.^[6]