SLC26A6

SLC26A6
Identifiers
Aliases	SLC26A6, solute carrier family 26 member 6
External IDs	OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,635,493 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,742,117 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; oocyte; ; rectum; ; stromal cell of endometrium; ; left coronary artery; ; body of stomach;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; primary oocyte; ; yolk sac; ; pancreas; ; muscle tissue; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; formate transmembrane transporter activity; chloride transmembrane transporter activity; anion transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; formate efflux transmembrane transporter activity; oxalate transmembrane transporter activity; protein binding; efflux transmembrane transporter activity; antiporter activity; chloride channel activity; inorganic anion exchanger activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; vesicle membrane; plasma membrane; integral component of plasma membrane; chloride channel complex; brush border membrane; basolateral plasma membrane; apical plasma membrane; endoplasmic reticulum; sperm midpiece; cytoplasmic vesicle membrane; cytoplasmic vesicle; intracellular anatomical structure; vesicle;
Biological process	oxalic acid secretion; mannitol transport; oxalate transport; formate transport; intracellular pH elevation; sulfate transport; epithelial fluid transport; angiotensin-activated signaling pathway; regulation of membrane potential; regulation of intracellular pH; cellular response to fructose stimulus; ion transport; transepithelial chloride transport; protein kinase C signaling; anion transport; transepithelial transport; cellular response to interferon-gamma; sperm capacitation; intestinal absorption; chloride transport; positive regulation of dipeptide transmembrane transport; cellular response to cAMP; anion transmembrane transport; sulfate transmembrane transport; bicarbonate transport; transmembrane transport; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	65010
	171429
	ENSG00000225697
	ENSMUSG00000023259
	Q9BXS9
	Q8CIW6
NM_134426; NM_001040454; NM_001281732; NM_001281733; NM_022911;
	NM_134263
	NM_134420
NP_001035544; NP_001268661; NP_001268662; NP_075062; NP_599025;
	NP_602298; NP_001035544.1
	NP_599252; NP_001395316
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.^[5]^[6]^[7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.^[8]

AliasesSLC26A6, solute carrier family 26 member 6

External IDsOMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs

Chr.Chromosome 3 (human)^[1]

End48,635,493 bp^[1]

Quick facts Identifiers, Aliases ...

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This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.^[7]

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

SLC26A6

Associated diseases

See also

References

Further reading

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