Long-chain fatty acid transport protein 4

SLC27A4
Identifiers
Aliases	SLC27A4, ACSVL4, FATP4, IPS, solute carrier family 27 member 4
External IDs	OMIM: 604194; MGI: 1347347; HomoloGene: 68437; GeneCards: SLC27A4; OMA:SLC27A4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,361,470 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,707,534 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; jejunal mucosa; ; duodenum; ; skin of arm; ; mucosa of ileum; ; prefrontal cortex; ; right frontal lobe; ; skin of leg; ; Brodmann area 9; ; hypothalamus;
	Top expressed in
	lip; ; granulocyte; ; jejunum; ; duodenum; ; ileum; ; skin of external ear; ; esophagus; ; pontine nuclei; ; skin of abdomen; ; medial dorsal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; fatty acid transmembrane transporter activity; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; plasma membrane; microvillus; brush border membrane; endoplasmic reticulum;
Biological process	lipid transport; response to nutrient; lipid metabolism; medium-chain fatty acid transport; very long-chain fatty acid metabolic process; fatty acid transport; fatty acid metabolic process; long-chain fatty acid import into cell; very long-chain fatty acid catabolic process; metabolism; long-chain fatty acid metabolic process; skin development; long-chain fatty acid transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	10999
	26569
	ENSG00000167114
	ENSMUSG00000059316
	Q6P1M0
	Q91VE0
	NM_005094
	NM_011989
	NP_005085; NP_005085.2
	NP_036119
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.^[5]^[6] This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.^[7] It is debated whether it is also a fatty acid transporter at the plasma membrane.^[8]