Vesicular inhibitory amino acid transporter

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.^[5]

AliasesSLC32A1, VGAT, VIAAT, solute carrier family 32 member 1

External IDsOMIM: 616440; MGI: 1194488; HomoloGene: 56451; GeneCards: SLC32A1; OMA:SLC32A1 - orthologs

Chr.Chromosome 20 (human)^[1]

End38,729,372 bp^[1]

Quick facts SLC32A1, Identifiers ...

SLC32A1
Identifiers
Aliases	SLC32A1, VGAT, VIAAT, solute carrier family 32 member 1
External IDs	OMIM: 616440; MGI: 1194488; HomoloGene: 56451; GeneCards: SLC32A1; OMA:SLC32A1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 38,724,486 bp[1] End 38,729,372 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 158,452,687 bp[2] End 158,457,668 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens putamen prefrontal cortex caudate nucleus endothelial cell external globus pallidus cingulate gyrus anterior cingulate cortex middle temporal gyrus right frontal lobe Top expressed in dorsal tegmental nucleus nucleus accumbens nucleus of stria terminalis lateral septal nucleus superior colliculus globus pallidus central gray substance of midbrain medulla oblongata Rostral migratory stream olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycine transmembrane transporter activity amino acid transmembrane transporter activity gamma-aminobutyric acid:proton symporter activity Cellular component integral component of membrane membrane synaptic vesicle plasma membrane clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane synapse inhibitory synapse synaptic vesicle membrane presynaptic active zone dendrite terminus dendrite cone cell pedicle intracellular organelle cell tip neuron projection neuron projection terminus cytoplasmic vesicle membrane cytoplasmic vesicle integral component of synaptic vesicle membrane GABA-ergic synapse Biological process amino acid transmembrane transport ageing ion transport gamma-aminobutyric acid transport neurotransmitter transport hippocampus development neurotransmitter secretion glycine transport neurotransmitter loading into synaptic vesicle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140679 22348 Ensembl ENSG00000101438 ENSMUSG00000037771 UniProt Q9H598 O35633 RefSeq (mRNA) NM_080552 NM_009508 RefSeq (protein) NP_542119 NP_033534 Location (UCSC) Chr 20: 38.72 – 38.73 Mb Chr 2: 158.45 – 158.46 Mb PubMed search [3] [4]
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The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.^[5]