SLC35C2

Solute carrier family 35 member C2 is a protein that in humans is encoded by the SLC35C2 gene.^[5][6][7]

AliasesSLC35C2, BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2

External IDsMGI: 2385166; HomoloGene: 6581; GeneCards: SLC35C2; OMA:SLC35C2 - orthologs

Chr.Chromosome 20 (human)^[1]

End46,364,458 bp^[1]

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SLC35C2
Identifiers
Aliases	SLC35C2, BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2
External IDs	MGI: 2385166; HomoloGene: 6581; GeneCards: SLC35C2; OMA:SLC35C2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,345,980 bp[1] End 46,364,458 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.53 cM Start 165,118,474 bp[2] End 165,129,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii right uterine tube granulocyte left lobe of thyroid gland right lobe of thyroid gland stromal cell of endometrium right adrenal cortex left adrenal cortex right ovary minor salivary glands Top expressed in lacrimal gland granulocyte duodenum right kidney dentate gyrus of hippocampal formation granule cell yolk sac jejunum superior frontal gyrus primary visual cortex muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antiporter activity transmembrane transporter activity Cellular component integral component of membrane cis-Golgi network endoplasmic reticulum-Golgi intermediate compartment membrane membrane endoplasmic reticulum-Golgi intermediate compartment nucleoplasm Golgi apparatus Biological process protein O-linked fucosylation fucosylation negative regulation of gene expression positive regulation of Notch signaling pathway UDP-glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51006 228875 Ensembl ENSG00000080189 ENSMUSG00000017664 UniProt Q9NQQ7 Q8VCX2 RefSeq (mRNA) NM_001281457 NM_001281458 NM_001281459 NM_001281460 NM_015945 NM_173073 NM_173179 NM_001252573 NM_001252574 NM_001252575 NM_144893 NM_001363015 NM_001363016 RefSeq (protein) NP_001268386 NP_001268387 NP_001268388 NP_001268389 NP_057029 NP_775096 NP_775271 NP_001239502 NP_001239503 NP_001239504 NP_659142 NP_001349944 NP_001349945 Location (UCSC) Chr 20: 46.35 – 46.36 Mb Chr 2: 165.12 – 165.13 Mb PubMed search [3] [4]
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Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.^[7]