Putative sodium-coupled neutral amino acid transporter 10
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Putative sodium-coupled neutral amino acid transporter 10, also known as solute carrier family 38 member 10,[5] is a protein that in humans is encoded by the SLC38A10 gene.[6]
| SLC38A10 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SLC38A10, PP1744, solute carrier family 38 member 10 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 616525; MGI: 1919305; HomoloGene: 41556; GeneCards: SLC38A10; OMA:SLC38A10 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Cellular localization
Cellular localization study of SLC38A10 protein was investigated on different cell lines and primary cortex neuronal cells using Immunocytochemistry and GFP SLC38A10 vector. SLC38A10 localized on Golgi apparatus and ER organelles.[7]
Recent study on SLC38A10 knockout model provided some insight on possible association with p53 protein and cell survival.[8]
Cancer
A SLC38A family member has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[9] For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[9]
