Zinc transporter ZIP6

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.^[5][6][7]

AliasesSLC39A6, LIV-1, ZIP6, solute carrier family 39 member 6, LIV1

External IDsOMIM: 608731; MGI: 2147279; HomoloGene: 8199; GeneCards: SLC39A6; OMA:SLC39A6 - orthologs

Chr.Chromosome 18 (human)^[1]

End36,129,385 bp^[1]

Quick facts SLC39A6, Identifiers ...

SLC39A6
Identifiers
Aliases	SLC39A6, LIV-1, ZIP6, solute carrier family 39 member 6, LIV1
External IDs	OMIM: 608731; MGI: 2147279; HomoloGene: 8199; GeneCards: SLC39A6; OMA:SLC39A6 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.2 Start 36,108,531 bp[1] End 36,129,385 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A2 Start 24,712,938 bp[2] End 24,736,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Epithelium of choroid plexus retinal pigment epithelium hair follicle tibia seminal vesicula gingival epithelium caput epididymis epithelium of lactiferous gland lactiferous duct Top expressed in hair follicle superior cervical ganglion saccule primary oocyte supraoptic nucleus condyle decidua molar otic vesicle zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion transmembrane transporter activity zinc ion transmembrane transporter activity Cellular component integral component of membrane cell surface plasma membrane integral component of plasma membrane lamellipodium membrane endoplasmic reticulum membrane Biological process metal ion transport zinc ion transmembrane transport zinc ion transport zinc ion import across plasma membrane ion transport cellular zinc ion homeostasis transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25800 106957 Ensembl ENSG00000141424 ENSMUSG00000024270 UniProt Q13433 Q8C145 RefSeq (mRNA) NM_001099406 NM_012319 NM_139143 RefSeq (protein) NP_001092876 NP_036451 NP_631882 Location (UCSC) Chr 18: 36.11 – 36.13 Mb Chr 18: 24.71 – 24.74 Mb PubMed search [3] [4]
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Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]^[7]