Sodium–hydrogen antiporter 1

SLC9A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y4E, 2BEC, 2E30, 2KBV, 2L0E, 2MDF, 2YGG
Identifiers
Aliases	SLC9A1, APNH, NHE-1, NHE1, PPP1R143, LIKNS, Sodium–hydrogen antiporter 1, solute carrier family 9 member A1
External IDs	OMIM: 107310; MGI: 102462; HomoloGene: 20660; GeneCards: SLC9A1; OMA:SLC9A1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,166,981 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,151,013 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; mucosa of transverse colon; ; oocyte; ; placenta; ; body of stomach; ; stromal cell of endometrium; ; pylorus; ; putamen; ; mucosa of urinary bladder; ; nasal epithelium;
	Top expressed in
	epithelium of stomach; ; zygote; ; ankle joint; ; pyloric antrum; ; secondary oocyte; ; mucous cell of stomach; ; gastrula; ; granulocyte; ; decidua; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; calcium-dependent protein binding; phosphatidylinositol-4,5-bisphosphate binding; antiporter activity; solute:proton antiporter activity; sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential; calmodulin binding; protein binding; molecular adaptor activity; protein phosphatase 2B binding; sodium:proton antiporter activity; potassium:proton antiporter activity;
Cellular component	cytoplasm; membrane; focal adhesion; T-tubule; mitochondrion; perinuclear region of cytoplasm; cation-transporting ATPase complex; cell surface; apical plasma membrane; endoplasmic reticulum; membrane raft; extracellular exosome; lamellipodium; integral component of membrane; intercalated disc; plasma membrane; nucleoplasm; endoplasmic reticulum membrane; integral component of plasma membrane; basolateral plasma membrane; sarcolemma;
Biological process	regulation of cardiac muscle contraction by calcium ion signaling; regulation of sensory perception of pain; positive regulation of the force of heart contraction; positive regulation of cardiac muscle hypertrophy; cellular response to epinephrine stimulus; positive regulation of action potential; cellular response to mechanical stimulus; maintenance of cell polarity; cellular response to hypoxia; positive regulation of mitochondrial membrane permeability; response to muscle stretch; proton transmembrane transport; cellular sodium ion homeostasis; cardiac muscle cell differentiation; ion transport; positive regulation of cell growth; cellular response to insulin stimulus; regulation of focal adhesion assembly; regulation of cardiac muscle cell membrane potential; response to acidic pH; cell differentiation; regulation of the force of heart contraction; cellular response to organic cyclic compound; cellular response to acidic pH; cation transport; negative regulation of apoptotic process; regulation of the force of heart contraction by cardiac conduction; regulation of pH; cardiac muscle cell contraction; neuron death; hyaluronan catabolic process; response to organic cyclic compound; sodium ion transport; regulation of intracellular pH; positive regulation of intracellular signal transduction; regulation of stress fiber assembly; positive regulation of calcineurin-NFAT signaling cascade; protein complex oligomerization; sodium ion import across plasma membrane; positive regulation of apoptotic process; cellular response to antibiotic; positive regulation of calcium:sodium antiporter activity; cell migration; positive regulation of transcription by RNA polymerase II; cellular response to electrical stimulus; potassium ion transmembrane transport; transmembrane transport; transport; cellular response to cold; sodium ion export across plasma membrane; anion transmembrane transport; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6548
	20544
	ENSG00000090020
	ENSMUSG00000028854
	P19634
	Q61165
	NM_003047
	NM_016981; NM_001358455
	NP_003038
	NP_058677; NP_001345384
	Wikidata
View/Edit Human	View/Edit Mouse

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.^[5]