SLIT2

SLIT2
Available structures
PDB	Ortholog search: H0Y9Z6 PDBe H0Y9Z6 RCSB
List of PDB id codes
	2V70, 2V9S, 2V9T, 2WFH
Identifiers
Aliases	SLIT2, SLIL3, Slit-2, slit guidance ligand 2
External IDs	OMIM: 603746; MGI: 1315205; HomoloGene: 3516; GeneCards: SLIT2; OMA:SLIT2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	20,620,561 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	48,465,075 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; olfactory bulb; ; vena cava; ; trigeminal ganglion; ; right lung; ; spinal ganglia; ; urethra; ; pericardium; ; parietal pleura; ; middle temporal gyrus;
	Top expressed in
	floor plate; ; ciliary body; ; sciatic nerve; ; vas deferens; ; Epithelium of choroid plexus; ; body of femur; ; iris; ; left lung lobe; ; medullary collecting duct; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; heparin binding; protein homodimerization activity; GTPase inhibitor activity; laminin-1 binding; protein binding; identical protein binding; Roundabout binding; proteoglycan binding;
Cellular component	cytoplasm; membrane; extracellular region; cell surface; extracellular exosome; plasma membrane; extracellular space;
Biological process	negative regulation of protein phosphorylation; negative regulation of chemokine-mediated signaling pathway; negative regulation of neutrophil chemotaxis; negative regulation of cellular response to growth factor stimulus; chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration; cell differentiation; ureteric bud development; negative chemotaxis; negative regulation of actin filament polymerization; negative regulation of small GTPase mediated signal transduction; negative regulation of retinal ganglion cell axon guidance; negative regulation of mononuclear cell migration; corticospinal neuron axon guidance through spinal cord; negative regulation of smooth muscle cell migration; Roundabout signaling pathway; positive regulation of axonogenesis; nervous system development; cell migration involved in sprouting angiogenesis; negative regulation of endothelial cell migration; axon guidance; multicellular organism development; chemotaxis; negative regulation of smooth muscle cell chemotaxis; cellular response to hormone stimulus; negative regulation of cell migration; negative regulation of monocyte chemotaxis; negative regulation of cell growth; response to cortisol; apoptotic process involved in luteolysis; positive regulation of apoptotic process; induction of negative chemotaxis; cellular response to heparin; motor neuron axon guidance; branching morphogenesis of an epithelial tube; negative regulation of leukocyte chemotaxis; chemorepulsion involved in postnatal olfactory bulb interneuron migration; axon extension involved in axon guidance; negative regulation of lamellipodium assembly; negative regulation of vascular permeability; retinal ganglion cell axon guidance; negative regulation of GTPase activity; aortic valve morphogenesis; pulmonary valve morphogenesis; ventricular septum morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9353
	20563
	ENSG00000145147
	ENSMUSG00000031558
	O94813
	Q9R1B9
	NM_001289135; NM_001289136; NM_004787
	NM_001291227; NM_001291228; NM_178804
	NP_001276064; NP_001276065; NP_004778
	NP_001278156; NP_001278157; NP_848919
	Wikidata
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