SMAP1

Stromal membrane-associated protein 1 is a protein that in humans is encoded by the SMAP1 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesSMAP1, SMAP-1, small ArfGAP 1

External IDsOMIM: 611372; MGI: 2138261; HomoloGene: 134676; GeneCards: SMAP1; OMA:SMAP1 - orthologs

Chr.Chromosome 6 (human)^[1]

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SMAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRR
Identifiers
Aliases	SMAP1, SMAP-1, small ArfGAP 1
External IDs	OMIM: 611372; MGI: 2138261; HomoloGene: 134676; GeneCards: SMAP1; OMA:SMAP1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q13 Start 70,667,776 bp[1] End 70,862,011 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A5 Start 23,883,927 bp[2] End 23,961,398 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon oral cavity pons mucosa of pharynx duodenum skin of thigh skin of hip islet of Langerhans ganglionic eminence Top expressed in blood genital tubercle tail of embryo seminiferous tubule spermatid dentate gyrus of hippocampal formation granule cell neural layer of retina superior frontal gyrus calvaria gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding metal ion binding GTPase activator activity Cellular component cytoplasm plasma membrane membrane Biological process positive regulation of GTPase activity regulation of clathrin-dependent endocytosis positive regulation of erythrocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60682 98366 Ensembl ENSG00000112305 ENSMUSG00000026155 UniProt Q8IYB5 Q91VZ6 RefSeq (mRNA) NM_001044305 NM_001281439 NM_001281440 NM_021940 NM_001290683 NM_028534 NM_001357395 RefSeq (protein) NP_001037770 NP_001268368 NP_001268369 NP_068759 NP_001277612 NP_082810 NP_001344324 Location (UCSC) Chr 6: 70.67 – 70.86 Mb Chr 1: 23.88 – 23.96 Mb PubMed search [3] [4]
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The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms.^[7]