SMARCC2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.[5][6][7]

AliasesSMARCC2, BAF170, CRACC2, Rsc8, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2, CSS8
End56,189,567 bp[1]
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SMARCC2
Identifiers
AliasesSMARCC2, BAF170, CRACC2, Rsc8, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2, CSS8
External IDsOMIM: 601734; MGI: 1915344; HomoloGene: 2312; GeneCards: SMARCC2; OMA:SMARCC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130420
NM_003075
NM_139067
NM_001330288

NM_001114096
NM_001114097
NM_198160
NM_001372395

RefSeq (protein)

NP_001123892
NP_001317217
NP_003066
NP_620706

NP_001107568
NP_001107569
NP_937803
NP_001359324

Location (UCSC)Chr 12: 56.16 – 56.19 MbChr 10: 128.3 – 128.33 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

SMARCC2 has been shown to interact with SMARCA4.[8][9][10]

References

Further reading

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