SMARCD1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesSMARCD1, BAF60A, CRACD1, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, CSS11

External IDsOMIM: 601735; MGI: 1933623; HomoloGene: 20670; GeneCards: SMARCD1; OMA:SMARCD1 - orthologs

Chr.Chromosome 12 (human)^[1]

Quick facts Available structures, PDB ...

SMARCD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UHR
Identifiers
Aliases	SMARCD1, BAF60A, CRACD1, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, CSS11
External IDs	OMIM: 601735; MGI: 1933623; HomoloGene: 20670; GeneCards: SMARCD1; OMA:SMARCD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 50,085,200 bp[1] End 50,100,707 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.13 cM Start 99,600,010 bp[2] End 99,611,872 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right lobe of thyroid gland left lobe of thyroid gland right ovary cardia right hemisphere of cerebellum body of uterus left ovary granulocyte Top expressed in superior frontal gyrus ventricular zone epiblast primary visual cortex tail of embryo neural tube dentate gyrus of hippocampal formation granule cell genital tubercle olfactory tubercle entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity transcription coactivator activity chromatin binding protein binding signaling receptor binding Cellular component npBAF complex nBAF complex nucleus nucleoplasm intracellular membrane-bounded organelle SWI/SNF complex Biological process regulation of transcription by RNA polymerase II chromatin remodeling nucleosome disassembly cellular response to fatty acid nervous system development chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6602 83797 Ensembl ENSG00000066117 ENSMUSG00000023018 UniProt Q96GM5 Q61466 RefSeq (mRNA) NM_003076 NM_139071 NM_031842 RefSeq (protein) NP_003067 NP_620710 NP_114030 Location (UCSC) Chr 12: 50.09 – 50.1 Mb Chr 15: 99.6 – 99.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.^[8]