SMOC2

Protein From Wikipedia, the free encyclopedia

SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.[5][6]

AliasesSMOC2, DTDP1, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1, SPARC related modular calcium binding 2
End168,673,445 bp[1]
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SMOC2
Identifiers
AliasesSMOC2, DTDP1, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1, SPARC related modular calcium binding 2
External IDsOMIM: 607223; MGI: 1929881; HomoloGene: 11150; GeneCards: SMOC2; OMA:SMOC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166412
NM_022138

NM_022315

RefSeq (protein)

NP_001159884
NP_071421

NP_071710

Location (UCSC)Chr 6: 168.44 – 168.67 MbChr 17: 14.5 – 14.63 Mb
PubMed search[3][4]
Wikidata
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Clinical relevance

This gene has been shown mutated in clinical cases of major dental developmental defects.[7]

Brachycephalic dogs show a shortening of the snout along with a widening of the hard palate. This skull form is highly associated with disorders of breathing and of the eyes. Brachycephaly in dogs is correlated to a retrotransposon induced missplicing the SMOC2 gene.[8]

References

Further reading

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