SND1

SND1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6N, 2HQE, 2HQX, 2O4X, 3BDL, 3OMC, 3OMG, 4QMG
Identifiers
Aliases	SND1, TDRD11, p100, staphylococcal nuclease and tudor domain containing 1, Tudor-SN
External IDs	OMIM: 602181; MGI: 1929266; HomoloGene: 8665; GeneCards: SND1; OMA:SND1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,092,609 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,935,161 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; stromal cell of endometrium; ; islet of Langerhans; ; parotid gland; ; epithelium of colon; ; canal of the cervix; ; left ovary; ; smooth muscle tissue; ; anterior pituitary; ; right ovary;
	Top expressed in
	lacrimal gland; ; parotid gland; ; dentate gyrus of hippocampal formation granule cell; ; yolk sac; ; lip; ; epiblast; ; ventricular zone; ; molar; ; stroma of bone marrow; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; transcription coregulator activity; nucleic acid binding; nuclease activity; RNA binding; cadherin binding; endonuclease activity; endoribonuclease activity; hydrolase activity; RISC complex binding;
Cellular component	melanosome; RISC complex; extracellular exosome; mitochondrion; membrane; dense body; cytoplasm; cytosol; nucleus;
Biological process	gene silencing; viral process; regulation of transcription, DNA-templated; osteoblast differentiation; transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; RNA catabolic process; regulation of cell cycle process; miRNA catabolic process; RNA phosphodiester bond hydrolysis, endonucleolytic; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	27044
	56463
	ENSG00000197157
	ENSMUSG00000001424
	Q7KZF4
	Q78PY7
	NM_014390
	NM_019776
	NP_055205
	NP_062750
	Wikidata
View/Edit Human	View/Edit Mouse

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.^[5]^[6]^[7]^[8] SND1 is a main component of RISC complex^[9] and plays an important role in miRNA function.^[10]^[11] SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.^[12] SND1 is also involved in Autism.^[13]