SNW1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.[5][6][7]
Function
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.[7]
Interactions
SNW1 has been shown to interact with:
- CIR,[8]
- Calcitriol receptor,[6][9]
- Histone deacetylase 2,[8]
- Mothers against decapentaplegic homolog 2,[10]
- Mothers against decapentaplegic homolog 3,[10]
- NOTCH1[11][12]
- Nuclear receptor co-repressor 2,[8][11]
- Nuclear receptor coactivator 1,[9]
- PABPN1,[13]
- RBPJ,[8][11]
- Retinoblastoma protein,[14] and
- SKI protein.[15][16][10]