SNX15

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.^[4][5]

AliasesSNX15, HSAF001435, sorting nexin 15

External IDsOMIM: 605964; MGI: 1916274; HomoloGene: 12294; GeneCards: SNX15; OMA:SNX15 - orthologs

Chr.Chromosome 19 (mouse)^[1]

End6,178,334 bp^[1]

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SNX15
Identifiers
Aliases	SNX15, HSAF001435, sorting nexin 15
External IDs	OMIM: 605964; MGI: 1916274; HomoloGene: 12294; GeneCards: SNX15; OMA:SNX15 - orthologs
Gene location (Mouse) Chr. Chromosome 19 (mouse)[1] Band 19|19 A Start 6,169,429 bp[1] End 6,178,334 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell prefrontal cortex cerebellar hemisphere monocyte skeletal muscle tissue gastrocnemius muscle popliteal artery right coronary artery Brodmann area 9 amygdala Top expressed in blood neural layer of retina superior frontal gyrus fetal liver hematopoietic progenitor cell islet of Langerhans yolk sac lip gastric mucosa primary visual cortex epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol binding lipid binding Cellular component nucleolus cytoplasmic vesicle membrane membrane cytoplasmic vesicle cytoplasm cytosol Biological process protein transport signal transduction intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29907 69024 Ensembl n/a ENSMUSG00000024787 UniProt Q9NRS6 Q91WE1 RefSeq (mRNA) NM_147777 NM_013306 NM_026912 RefSeq (protein) NP_037438 NP_680086 NP_081188 Location (UCSC) n/a Chr 19: 6.17 – 6.18 Mb PubMed search [2] [3]
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membranee to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.^[5]