SOCS4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesSOCS4, SOCS7, suppressor of cytokine signaling 4
Quick facts Available structures, PDB ...
SOCS4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSOCS4, SOCS7, suppressor of cytokine signaling 4
External IDsOMIM: 616337; MGI: 1914546; HomoloGene: 15442; GeneCards: SOCS4; OMA:SOCS4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080867
NM_199421

NM_080843

RefSeq (protein)

NP_543143
NP_955453

NP_543119

Location (UCSC)Chr 14: 55.03 – 55.05 MbChr 14: 47.51 – 47.53 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

Further reading

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