SOCS6

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesSOCS6, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6

External IDsOMIM: 605118; MGI: 1924885; HomoloGene: 3120; GeneCards: SOCS6; OMA:SOCS6 - orthologs

Chr.Chromosome 18 (human)^[1]

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SOCS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VIF
Identifiers
Aliases	SOCS6, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6
External IDs	OMIM: 605118; MGI: 1924885; HomoloGene: 3120; GeneCards: SOCS6; OMA:SOCS6 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q22.2 Start 70,289,045 bp[1] End 70,330,199 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E4 Start 88,683,348 bp[2] End 88,945,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus biceps brachii Skeletal muscle tissue of rectus abdominis jejunal mucosa oral cavity mucosa of colon mucosa of sigmoid colon Skeletal muscle tissue of biceps brachii right ventricle caput epididymis Top expressed in otic vesicle otic placode zygote saccule secondary oocyte pineal gland yolk sac intercostal muscle soleus muscle medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity protein binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm immunological synapse cytosol phosphatidylinositol 3-kinase complex Biological process regulation of growth defense response proteasomal protein catabolic process receptor signaling pathway via JAK-STAT negative regulation of signal transduction intracellular signal transduction negative regulation of T cell activation protein ubiquitination negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT post-translational protein modification regulation of phosphatidylinositol 3-kinase activity phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9306 54607 Ensembl ENSG00000170677 ENSMUSG00000056153 UniProt O14544 Q9JLY0 RefSeq (mRNA) NM_004232 NM_016387 NM_018821 RefSeq (protein) NP_004223 NP_061291 Location (UCSC) Chr 18: 70.29 – 70.33 Mb Chr 18: 88.68 – 88.95 Mb PubMed search [3] [4]
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The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.^[7]