SOSTDC1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[5]
Function
This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[5]
Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.[6][7][8]
