SOX11
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.[5][6][7]
Function
This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.[7][8] Tuj1 and Tead2 are suggested as direct target of Sox11.[9][10][11]
Clinical aspect
Lymphocyte staining for SOX11 immunohistochemistry indicates mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes.[12]
Mutations in SOX11 are associated with Coffin–Siris syndrome[13] and mantle cell lymphoma.[14]
