SPA17

Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.^[5][6]

AliasesSPA17, CT22, SP17, SP17-1, sperm autoantigenic protein 17

External IDsOMIM: 608621; MGI: 1333778; HomoloGene: 7951; GeneCards: SPA17; OMA:SPA17 - orthologs

Chr.Chromosome 11 (human)^[1]

End124,697,518 bp^[1]

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SPA17
Identifiers
Aliases	SPA17, CT22, SP17, SP17-1, sperm autoantigenic protein 17
External IDs	OMIM: 608621; MGI: 1333778; HomoloGene: 7951; GeneCards: SPA17; OMA:SPA17 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,673,844 bp[1] End 124,697,518 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 37,514,586 bp[2] End 37,525,018 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell sperm left testis right testis olfactory zone of nasal mucosa mucosa of paranasal sinus right uterine tube caput epididymis Epithelium of choroid plexus epithelium of nasopharynx Top expressed in seminiferous tubule spermatid olfactory epithelium spermatocyte choroidal fissure right kidney lumbar spinal ganglion right lung lobe ventricular zone islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding calmodulin binding Cellular component cytoplasm sperm principal piece motile cilium sperm fibrous sheath external side of plasma membrane membrane cilium extracellular region Biological process epithelial cilium movement involved in extracellular fluid movement spermatogenesis single fertilization binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53340 20686 Ensembl ENSG00000064199 ENSMUSG00000001948 UniProt Q15506 Q62252 RefSeq (mRNA) NM_017425 NM_011449 NM_001324545 RefSeq (protein) NP_059121 NP_001311474 NP_035579 Location (UCSC) Chr 11: 124.67 – 124.7 Mb Chr 9: 37.51 – 37.53 Mb PubMed search [3] [4]
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This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.^[6]