SPPL2A

SPPL2A
Identifiers
Aliases	SPPL2A, IMP3, PSL2, signal peptide peptidase like 2A, IMD86
External IDs	OMIM: 608238; MGI: 1913802; HomoloGene: 36411; GeneCards: SPPL2A; OMA:SPPL2A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	50,765,709 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	126,933,235 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; secondary oocyte; ; tibialis anterior muscle; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; cartilage tissue; ; rectum; ; mucosa of colon;
	Top expressed in
	body of femur; ; submandibular gland; ; ascending aorta; ; aortic valve; ; calvaria; ; stroma of bone marrow; ; left lobe of liver; ; knee joint; ; mesenteric lymph nodes; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; aspartic-type endopeptidase activity; peptidase activity; protein binding; hydrolase activity; aspartic endopeptidase activity, intramembrane cleaving;
Cellular component	integral component of membrane; endosome; late endosome; membrane; late endosome membrane; intracellular membrane-bounded organelle; integral component of cytoplasmic side of endoplasmic reticulum membrane; lysosomal membrane; Golgi-associated vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; extracellular exosome; plasma membrane;
Biological process	membrane protein proteolysis; proteolysis; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; regulation of immune response; regulation of tumor necrosis factor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84888
	66552
	ENSG00000138600
	ENSMUSG00000027366
	Q8TCT8
	Q9JJF9
	NM_032802
	NM_023220
	NP_116191
	NP_075709
	Wikidata
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