SRA1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.[5][6] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.[7]
Function
This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.[6]
Interactions
SRA1 has been shown to interact with:
- Estrogen receptor alpha,[unreliable source?]
- DDX17,[unreliable source?]
- Nuclear receptor coactivator 2,[unreliable source?] and
- SPEN.[8]
The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA.[9] Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.[10]