Sterol regulatory element–binding protein 2

SREBF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UKL
Identifiers
Aliases	SREBF2, SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2
External IDs	OMIM: 600481; MGI: 107585; HomoloGene: 20966; GeneCards: SREBF2; OMA:SREBF2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,907,307 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,089,580 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; right hemisphere of cerebellum; ; right adrenal cortex; ; left adrenal cortex; ; right frontal lobe; ; tibial nerve; ; prefrontal cortex; ; cingulate gyrus; ; mucosa of transverse colon;
	Top expressed in
	ventricular zone; ; lip; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; neural tube; ; yolk sac; ; granulocyte; ; neural layer of retina; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	C-8 sterol isomerase activity; DNA binding; protein dimerization activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein C-terminus binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; integral component of membrane; cytosol; SREBP-SCAP-Insig complex; Golgi apparatus; endoplasmic reticulum membrane; membrane; Golgi membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; cytoplasmic vesicle; nucleus; nucleoplasm; mitochondrion; intracellular membrane-bounded organelle;
Biological process	steroid metabolic process; regulation of transcription, DNA-templated; positive regulation of protein targeting to mitochondrion; lipid metabolism; positive regulation of cholesterol storage; cellular response to laminar fluid shear stress; cellular response to starvation; cholesterol metabolic process; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of autophagy of mitochondrion; negative regulation of cholesterol efflux; positive regulation of transcription by RNA polymerase II; regulation of cholesterol biosynthetic process; cellular response to low-density lipoprotein particle stimulus;
	Sources:Amigo / QuickGO
Orthologs
	6721
	20788
	ENSG00000198911
	ENSMUSG00000022463
	Q12772
	Q3U1N2
	NM_004599
	NM_033218
	NP_004590
	NP_150087
	Wikidata
View/Edit Human	View/Edit Mouse

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.^[5]