SSH1

SSH1
Identifiers
Aliases	SSH1, SSH1L, slingshot protein phosphatase 1
External IDs	OMIM: 606778; MGI: 2686240; GeneCards: SSH1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	108,857,590 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,131,955 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; saphenous vein; ; secondary oocyte; ; trigeminal ganglion; ; lower lobe of lung; ; lactiferous duct; ; tail of epididymis; ; spinal ganglia; ; caput epididymis;
	Top expressed in
	internal carotid artery; ; Rostral migratory stream; ; external carotid artery; ; sciatic nerve; ; substantia nigra; ; fossa; ; blood; ; Gonadal ridge; ; ciliary body; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; actin binding; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity;
Cellular component	cytoplasm; cell projection; plasma membrane; midbody; cleavage furrow; cytoskeleton; lamellipodium; cytosol; growth cone; cell leading edge; membrane; integral component of membrane;
Biological process	regulation of lamellipodium assembly; protein dephosphorylation; regulation of axonogenesis; regulation of actin polymerization or depolymerization; cell morphogenesis; regulation of cellular protein metabolic process; peptidyl-tyrosine dephosphorylation; cellular response to ATP; actin cytoskeleton organization; dephosphorylation; positive regulation of synaptic plasticity; excitatory chemical synaptic transmission; positive regulation of neuron death; positive regulation of AMPA glutamate receptor clustering; positive regulation of vascular associated smooth muscle cell migration; positive regulation of excitatory postsynaptic potential;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54434
	231637
	ENSG00000084112
	ENSMUSG00000042121
	Q8WYL5
	Q76I79
	NM_001161330; NM_001161331; NM_018984
	NM_198109; NM_001363469
	NP_001154802; NP_001154803; NP_061857
	NP_932777; NP_001350398
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.^[5]^[6]^[7]

AliasesSSH1, SSH1L, slingshot protein phosphatase 1

External IDsOMIM: 606778; MGI: 2686240; GeneCards: SSH1

Chr.Chromosome 12 (human)^[1]

End108,857,590 bp^[1]

Quick facts Identifiers, Aliases ...

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The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[7]

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SSH1

References

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Related Articles

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin"

"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia"

"Large-scale characterization of HeLa cell nuclear phosphoproteins"

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"

"Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin"

"Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration"

"Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge"

"The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes"