SSH1

For the SSH-1 protocol, see Secure Shell#Version 1

AliasesSSH1, SSH1L, slingshot protein phosphatase 1

External IDsOMIM: 606778; MGI: 2686240; HomoloGene: 41299; GeneCards: SSH1; OMA:SSH1 - orthologs

Chr.Chromosome 12 (human)^[1]

End108,857,590 bp^[1]

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SSH1
Identifiers
Aliases	SSH1, SSH1L, slingshot protein phosphatase 1
External IDs	OMIM: 606778; MGI: 2686240; HomoloGene: 41299; GeneCards: SSH1; OMA:SSH1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 108,778,191 bp[1] End 108,857,590 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 114,075,155 bp[2] End 114,131,955 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium saphenous vein secondary oocyte trigeminal ganglion lower lobe of lung lactiferous duct tail of epididymis spinal ganglia caput epididymis Top expressed in internal carotid artery Rostral migratory stream external carotid artery sciatic nerve substantia nigra fossa blood Gonadal ridge ciliary body cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity actin binding hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cell projection plasma membrane midbody cleavage furrow cytoskeleton lamellipodium cytosol growth cone cell leading edge membrane integral component of membrane Biological process regulation of lamellipodium assembly protein dephosphorylation regulation of axonogenesis regulation of actin polymerization or depolymerization cell morphogenesis regulation of cellular protein metabolic process peptidyl-tyrosine dephosphorylation cellular response to ATP actin cytoskeleton organization dephosphorylation positive regulation of synaptic plasticity excitatory chemical synaptic transmission positive regulation of neuron death positive regulation of AMPA glutamate receptor clustering positive regulation of vascular associated smooth muscle cell migration positive regulation of excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54434 231637 Ensembl ENSG00000084112 ENSMUSG00000042121 UniProt Q8WYL5 Q76I79 RefSeq (mRNA) NM_001161330 NM_001161331 NM_018984 NM_198109 NM_001363469 RefSeq (protein) NP_001154802 NP_001154803 NP_061857 NP_932777 NP_001350398 Location (UCSC) Chr 12: 108.78 – 108.86 Mb Chr 5: 114.08 – 114.13 Mb PubMed search [3] [4]
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Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.^[5][6][7]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[7]