SSH2

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesSSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2

External IDsOMIM: 606779; MGI: 2679255; HomoloGene: 14116; GeneCards: SSH2; OMA:SSH2 - orthologs

Chr.Chromosome 17 (human)^[1]

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SSH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NT2
Identifiers
Aliases	SSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs	OMIM: 606779; MGI: 2679255; HomoloGene: 14116; GeneCards: SSH2; OMA:SSH2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 29,625,938 bp[1] End 29,930,276 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 77,107,113 bp[2] End 77,351,046 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle cardiac muscle tissue of right atrium blood Skeletal muscle tissue of rectus abdominis gastrocnemius muscle quadriceps femoris muscle Skeletal muscle tissue of biceps brachii vastus lateralis muscle white blood cell Top expressed in spermatocyte extraocular muscle digastric muscle temporal muscle sternocleidomastoid muscle interventricular septum soleus muscle vastus lateralis muscle triceps brachii muscle lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity actin binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cytoskeleton extracellular space Biological process regulation of lamellipodium assembly regulation of axonogenesis regulation of actin polymerization or depolymerization protein dephosphorylation peptidyl-tyrosine dephosphorylation actin cytoskeleton organization dephosphorylation cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85464 237860 Ensembl ENSG00000141298 ENSMUSG00000037926 UniProt Q76I76 Q5SW75 RefSeq (mRNA) NM_001282129 NM_001282130 NM_001282131 NM_033389 NM_001291190 NM_177710 RefSeq (protein) NP_001269058 NP_001269059 NP_001269060 NP_203747 NP_001278119 NP_808378 Location (UCSC) Chr 17: 29.63 – 29.93 Mb Chr 11: 77.11 – 77.35 Mb PubMed search [3] [4]
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The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[7]