SSR1

Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene.^[5]

AliasesSSR1, TRAPA, signal sequence receptor subunit 1

External IDsOMIM: 600868; MGI: 105082; HomoloGene: 2368; GeneCards: SSR1; OMA:SSR1 - orthologs

Chr.Chromosome 6 (human)^[1]

End7,347,446 bp^[1]

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SSR1
Identifiers
Aliases	SSR1, TRAPA, signal sequence receptor subunit 1
External IDs	OMIM: 600868; MGI: 105082; HomoloGene: 2368; GeneCards: SSR1; OMA:SSR1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.3 Start 7,268,306 bp[1] End 7,347,446 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.3 Start 38,150,581 bp[2] End 38,178,193 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis trabecular bone parotid gland tibia skin of hip tail of epididymis mucosa of sigmoid colon germinal epithelium gums Top expressed in calvaria molar cumulus cell lacrimal gland dermis gastrula abdominal wall condyle efferent ductule fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process IRE1-mediated unfolded protein response cotranslational protein targeting to membrane positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6745 107513 Ensembl ENSG00000124783 ENSMUSG00000021427 UniProt P43307 Q9CY50 RefSeq (mRNA) NM_001292008 NM_003144 NM_025965 NM_001360842 RefSeq (protein) NP_001278937 NP_003135 NP_080241 NP_001347771 Location (UCSC) Chr 6: 7.27 – 7.35 Mb Chr 13: 38.15 – 38.18 Mb PubMed search [3] [4]
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The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.^[5]