ST-1936

ST-1936
Clinical data
Other names	2-Methyl-5-chloro-N,N-dimethyltryptamine; 2-Methyl-5-chloro-DMT; 2-Me-5-Cl-DMT
ATC code	none;
Identifiers
	IUPAC name 2-(2-methyl-5-chloro-1H-indol-3-yl)-N,N-dimethylethanamine;
CAS Number	1210-81-7 ;
PubChem CID	9921064;
ChemSpider	8096699;
UNII	4R5ZNV2CHC;
ChEMBL	ChEMBL365751;
CompTox Dashboard (EPA)	DTXSID001045649 ;
Chemical and physical data
Formula	C13H17ClN2
Molar mass	236.74 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(CCN(C)C)C2=CC(Cl)=CC=C2N1;
	InChI InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3; Key:KSYMELKKLOFABL-UHFFFAOYSA-N;

ST-1936, also known as 2-methyl-5-chloro-N,N-dimethyltryptamine (2-methyl-5-chloro-DMT), is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor agonist, with a K_i of 13 nM, and much weaker action at 5-HT_2B and 5-HT₇ subtypes. In animal studies it has been found to increase dopamine and noradrenaline mediated signalling but decreases glutamatergic transmission, and has antidepressant effects.^[1]^[2]^[3]^[4]