ST13

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Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6, ST13 Hsp70 interacting protein
Quick facts Available structures, PDB ...
ST13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesST13, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6, ST13 Hsp70 interacting protein
External IDsOMIM: 606796; MGI: 1917606; HomoloGene: 2921; GeneCards: ST13; OMA:ST13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003932
NM_001278589

NM_133726

RefSeq (protein)

NP_001265518
NP_003923

NP_598487

Location (UCSC)Chr 22: 40.82 – 40.86 MbChr 15: 81.25 – 81.28 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.[7]

References

Further reading

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