STAP2

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesSTAP2, BKS, signal transducing adaptor family member 2

External IDsOMIM: 607881; MGI: 2147039; HomoloGene: 9798; GeneCards: STAP2; OMA:STAP2 - orthologs

Chr.Chromosome 19 (human)^[1]

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STAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EL8
Identifiers
Aliases	STAP2, BKS, signal transducing adaptor family member 2
External IDs	OMIM: 607881; MGI: 2147039; HomoloGene: 9798; GeneCards: STAP2; OMA:STAP2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,324,043 bp[1] End 4,342,786 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 56,304,077 bp[2] End 56,312,584 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum skin of abdomen skin of leg rectum olfactory zone of nasal mucosa mucosa of sigmoid colon pancreatic ductal cell right lobe of liver minor salivary glands Top expressed in intestinal villus jejunum ileum duodenum parotid gland epithelium of small intestine large intestine colon crypt of lieberkuhn of small intestine submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling adaptor activity Cellular component cytoplasm cytosol plasma membrane Biological process positive regulation of tyrosine phosphorylation of STAT protein positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55620 106766 Ensembl ENSG00000178078 ENSMUSG00000038781 UniProt Q9UGK3 Q8R0L1 RefSeq (mRNA) NM_001013841 NM_017720 NM_145934 RefSeq (protein) NP_001013863 NP_060190 NP_666046 Location (UCSC) Chr 19: 4.32 – 4.34 Mb Chr 17: 56.3 – 56.31 Mb PubMed search [3] [4]
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This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.^[7]