STARD13
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.[5][6]
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| Aliases | STARD13, ARHGAP37, DLC2, GT650, LINC00464, StAR related lipid transfer domain containing 13 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609866; MGI: 2385331; HomoloGene: 64844; GeneCards: STARD13; OMA:STARD13 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function and structure
STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.[7] It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.[7]
The protein consists of an N-terminal sterile alpha motif (SAM) domain,[8] a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).
Tissue distribution and pathology
The protein was identified in part through its differential expression in cancers. A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression. A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.[9]