STK4
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[5][6][7]
Function
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced mitogen-activated protein kinase (MAPK) cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.[8]
