SURF6

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene.^[5][6]

AliasesSURF6, RRP14, surfeit 6

External IDsOMIM: 185642; MGI: 98447; HomoloGene: 133981; GeneCards: SURF6; OMA:SURF6 - orthologs

Chr.Chromosome 9 (human)^[1]

End133,336,188 bp^[1]

Quick facts Identifiers, Aliases ...

SURF6
Identifiers
Aliases	SURF6, RRP14, surfeit 6
External IDs	OMIM: 185642; MGI: 98447; HomoloGene: 133981; GeneCards: SURF6; OMA:SURF6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,328,776 bp[1] End 133,336,188 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.08 cM Start 26,778,640 bp[2] End 26,792,891 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve mucosa of transverse colon gastrocnemius muscle substantia nigra C1 segment granulocyte temporal lobe small intestine amygdala hypothalamus Top expressed in epiblast external carotid artery internal carotid artery primitive streak ascending aorta supraoptic nucleus aortic valve lacrimal gland hair follicle prostate More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding RNA binding Cellular component nucleolus nucleus nucleoplasm granular component cytosolic large ribosomal subunit Biological process ribosome biogenesis ribosomal large subunit biogenesis ribosomal small subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6838 20935 Ensembl ENSG00000148296 ENSG00000281309 ENSMUSG00000036160 UniProt O75683 P70279 RefSeq (mRNA) NM_001278942 NM_006753 NM_009298 RefSeq (protein) NP_001265871 NP_006744 NP_033324 Location (UCSC) Chr 9: 133.33 – 133.34 Mb Chr 2: 26.78 – 26.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.^[6]