Sabcomeline

Sabcomeline (Memric; SB-202,026) is a selective M₁ receptor partial agonist that was under development for the treatment of Alzheimer's disease.^[1] It made it to phase III clinical trials before being discontinued due to poor results.

ATC code

• None

Legal status

• Never marketed

CAS Number

• 159912-53-5 ^Y
• HCl: 159912-58-0 ^Y

PubChem CID

• 9577995

Quick facts Clinical data, ATC code ...

Sabcomeline

Clinical data
ATC code	None
Legal status
Legal status	Never marketed
Identifiers
IUPAC name (3Z,3R)-N-methoxy-1-azabicyclo[2.2.2]octane-3-carboximidoyl cyanide
CAS Number	159912-53-5 Y HCl: 159912-58-0 Y
PubChem CID	9577995
IUPHAR/BPS	306
ChemSpider	7852359
UNII	P8P92V596C HCl: A24BK93DRR Y
ChEMBL	ChEMBL134641
CompTox Dashboard (EPA)	DTXSID101028868
Chemical and physical data
Formula	C10H15N3O
Molar mass	193.250 g·mol−1
3D model (JSmol)	Interactive image
SMILES C2CC1CCN2CC1\C(\C#N)=N\OC

Close

It is a non-selective agonist of all five muscarinic acetylcholine receptors with similar affinities.^[2] However, functional selectivity for the M₁ receptor has been claimed in vitro and in vivo.^[2]