Selective receptor modulator
From Wikipedia, the free encyclopedia
In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.[1] An SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.
| Selective receptor modulator | |
|---|---|
| Drug class | |
| |
| Class identifiers | |
| Synonyms | SRM |
| Use | Various |
| Biological target | Steroid hormone receptor |
| Chemical class | Steroidal; Nonsteroidal |
| Legal status | |
| In Wikidata | |
Classes
Classes of selective receptor modulators include:
- Selective androgen receptor modulator (SARM)
- Selective estrogen receptor modulator (SERM)
- Selective glucocorticoid receptor modulator (SEGRM)
- Selective progesterone receptor modulator (SPRM)
- Selective PPAR modulator (SPPARM) including SPPARMγ (affecting the PPARγ) and SPPARMα (PPARα)
