Senotherapy

Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence.^[1] Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells ^[2] and agents that inhibit the pro-inflammatory senescent secretome.^[3] Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.^[4] Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.^{[citation needed]}