Serglycin
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.[5] It is primarily expressed in hematopoietic cells and endothelial cells,[6] and is the only known intracellular proteoglycan.[7]
Function
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis.[5][8]
