Sivelestat

Sivelestat
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
ATC code	None;
Legal status
Legal status	US: Not approved; In general: ℞ (Prescription only);
Identifiers
	IUPAC name N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine;
CAS Number	127373-66-4 ;
PubChem CID	107706;
IUPHAR/BPS	6441;
ChemSpider	96875 ;
UNII	DWI62G0P59;
KEGG	D03788 ;
ChEMBL	ChEMBL76688 ;
CompTox Dashboard (EPA)	DTXSID9048304 ;
Chemical and physical data
Formula	C20H22N2O7S
Molar mass	434.46 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O;
	InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) ; Key:BTGNGJJLZOIYID-UHFFFAOYSA-N ;
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Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.^[1]

Quick facts Clinical data, AHFS/Drugs.com ...

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It is used in the treatment of acute respiratory failure^[2] and preliminary studies show it may also improve neuropathic pain.^[3]

Synthesis

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	IV
ATC code	None
Legal status
Legal status	US: Not approved In general: ℞ (Prescription only)
Identifiers
IUPAC name N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine
CAS Number	127373-66-4^N
PubChem CID	107706
IUPHAR/BPS	6441
ChemSpider	96875^Y
UNII	DWI62G0P59
KEGG	D03788^Y
ChEMBL	ChEMBL76688^Y
CompTox Dashboard (EPA)	DTXSID9048304
Chemical and physical data
Formula	C₂₀H₂₂N₂O₇S
Molar mass	434.46 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)^Y Key:BTGNGJJLZOIYID-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)