Spiperone
Chemical compound
From Wikipedia, the free encyclopedia
Spiperone, also known as spiroperidol and sold under the brand name Spiropitan ((JP)) is a typical antipsychotic of the butyrophenone family related to haloperidol.[1] It is approved for clinical use in Japan as a treatment for schizophrenia.[2]
- none
- Rx-only (JP)
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Metabolism | Hepatic |
| Excretion | Renal |
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| ECHA InfoCard | 100.010.931 |
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| Formula | C23H26FN3O2 |
| Molar mass | 395.478 g·mol−1 |
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Pharmacology
Pharmacodynamics
Spiperone interacts with various monoamine receptors.[5][3][6]
Additionally, spiperone was identified by compound screening to be an activator of Ca2+ activated Cl− channels (CaCCs), thus a potential target for therapy of cystic fibrosis.[7]
Chemistry
Derivatives
N-Methylspiperone (NMSP) is a derivative of spiperone that is used to study the dopamine and serotonin neurotransmitter system. Labeled with the radioisotope carbon-11, it can be used for positron emission tomography.[8]