SprX small RNA
RNA family
From Wikipedia, the free encyclopedia
In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.[3]
| SprX sRNA | |
|---|---|
Predicted secondary structure and sequence conservation of SprX small RNA | |
| Identifiers | |
| Rfam | RF02672 |
| Other data | |
| Domain | Bacteria |
| GO | GO:0040033 |
| SO | SO:0000370 |
| PDB structures | PDBe |
