Sulbactam
Chemical compound
From Wikipedia, the free encyclopedia
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.[1]
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| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a693021 |
| Routes of administration | Intravenous, intramuscular |
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| Pharmacokinetic data | |
| Protein binding | 29% |
| Elimination half-life | 0.65–1.20 hrs |
| Excretion | Mainly kidneys (41–66% within 8 hrs) |
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| ECHA InfoCard | 100.063.506 |
| Chemical and physical data | |
| Formula | C8H11NO5S |
| Molar mass | 233.24 g·mol−1 |
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| Melting point | 148 to 151 °C (298 to 304 °F) |
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It was patented in 1977 and approved for medical use in 1986.[2]
Medical uses
The combination ampicillin/sulbactam (Unasyn) is available in the United States.[3]
The combination cefoperazone/sulbactam (Sulperazon) is available in many countries but not in the United States.[4]
The co-packaged combination sulbactam/durlobactam was approved for medical use in the United States in May 2023.[5]
Mechanism
Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin.[6] Sulbactam itself contains a beta-lactam ring, and has weak antibacterial activity by inhibiting penicillin binding proteins (PBP) 1 and 3, but not 2.[7]