TAAR8

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.^[5][6][7] In humans, TAAR8 is the only trace amine-associated receptor that is known to be G_i/o-coupled.^[8]

AliasesTAAR8, GPR102, TA5, TAR5, TRAR5, TaR-5, TaR-8, trace amine associated receptor 8

External IDsOMIM: 606927; MGI: 2685995; HomoloGene: 77586; GeneCards: TAAR8; OMA:TAAR8 - orthologs

Chr.Chromosome 6 (human)^[1]

End132,553,721 bp^[1]

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TAAR8
Identifiers
Aliases	TAAR8, GPR102, TA5, TAR5, TRAR5, TaR-5, TaR-8, trace amine associated receptor 8
External IDs	OMIM: 606927; MGI: 2685995; HomoloGene: 77586; GeneCards: TAAR8; OMA:TAAR8 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 132,552,693 bp[1] End 132,553,721 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 23,967,158 bp[2] End 23,968,192 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreas female reproductive system organ system material anatomical entity kidney renal cortex vagina islet of Langerhans tibial nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function trace-amine receptor activity G protein-coupled receptor activity signal transducer activity Cellular component plasma membrane membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83551 382348 Ensembl ENSG00000146385 ENSMUSG00000100186 UniProt Q969N4 Q5QD06 RefSeq (mRNA) NM_053278 NM_001010837 RefSeq (protein) NP_444508 NP_001010837 Location (UCSC) Chr 6: 132.55 – 132.55 Mb Chr 10: 23.97 – 23.97 Mb PubMed search [3] [4]
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In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.^[9]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM^[7]