Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.[5][6]
AliasesTAAR9, TA3, TAR3, TAR9, TRAR3, trace amine associated receptor 9 (gene/pseudogene), trace amine associated receptor 9 Quick facts Identifiers, Aliases ...
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TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[7][8]
Recent research has demonstrated that deletion of the TAAR9 gene in rats leads to significant changes in both the CNS and the periphery. In the central nervous system, knockout of this gene slightly increases hippocampal serotonin and alters grooming behavior.[9] Peripherally, blood analysis revealed decreased levels of low-density lipoprotein cholesterol in the blood.[10] Additionally, TAAR9 appears to play a significant role in maintaining microbiota homeostasis. In TAAR9-KO rats, the microbiome structure exhibited greater variability than in wild-type littermates.[11]
