TAC4

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesTAC4, EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4

External IDsOMIM: 607833; MGI: 1931130; HomoloGene: 89219; GeneCards: TAC4; OMA:TAC4 - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

TAC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MOC
Identifiers
Aliases	TAC4, EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4
External IDs	OMIM: 607833; MGI: 1931130; HomoloGene: 89219; GeneCards: TAC4; OMA:TAC4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 49,838,300 bp[1] End 49,848,069 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 95,152,355 bp[2] End 95,160,091 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii buccal mucosa cell myocardium granulocyte vena cava cerebellar vermis anterior pituitary right lobe of thyroid gland blood left lobe of thyroid gland Top expressed in lip pineal gland olfactory epithelium tibiofemoral joint right ventricle skin of abdomen lumbar spinal ganglion aortic valve granulocyte medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding substance P receptor binding substance K receptor binding receptor ligand activity Cellular component extracellular region extracellular space Biological process regulation of blood pressure inflammatory response cell-cell signaling negative regulation of systemic arterial blood pressure tachykinin receptor signaling pathway regulation of signaling receptor activity detection of temperature stimulus involved in sensory perception of pain regulation of sensory perception of pain positive regulation of flagellated sperm motility negative regulation of sensory perception of pain positive regulation of sensory perception of pain positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255061 93670 Ensembl ENSG00000176358 ENSMUSG00000020872 UniProt Q86UU9 Q99N14 RefSeq (mRNA) NM_170685 NM_001077503 NM_001077504 NM_001077505 NM_001077506 NM_053093 RefSeq (protein) NP_001070971 NP_001070972 NP_001070973 NP_001070974 NP_733786 NP_444323 Location (UCSC) Chr 17: 49.84 – 49.85 Mb Chr 11: 95.15 – 95.16 Mb PubMed search [3] [4]
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This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]