TAF8

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesTAF8, 43, II, TAF, TAFII-43, TAFII43, TBN, TATA-box binding protein associated factor 8, TAF(II)43

External IDsOMIM: 609514; MGI: 1926879; HomoloGene: 11094; GeneCards: TAF8; OMA:TAF8 - orthologs

Chr.Chromosome 6 (human)^[1]

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TAF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WV6, 5FUR
Identifiers
Aliases	TAF8, 43, II, TAF, TAFII-43, TAFII43, TBN, TATA-box binding protein associated factor 8, TAF(II)43
External IDs	OMIM: 609514; MGI: 1926879; HomoloGene: 11094; GeneCards: TAF8; OMA:TAF8 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 42,050,513 bp[1] End 42,087,461 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 47,794,289 bp[2] End 47,813,217 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell apex of heart oocyte monocyte bone marrow cell left ventricle gastrocnemius muscle muscle of thigh tendon of biceps brachii appendix Top expressed in granulocyte secondary oocyte thymus zygote yolk sac neural layer of retina ventricular zone primary oocyte tail of embryo muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein heterodimerization activity Cellular component cytoplasm perinuclear region of cytoplasm nucleus nucleoplasm transcription factor TFIID complex Biological process positive regulation of transcription, DNA-templated multicellular organism development cell differentiation regulation of transcription, DNA-templated regulation of fat cell differentiation transcription, DNA-templated maintenance of protein location in nucleus inner cell mass cell proliferation snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 129685 63856 Ensembl ENSG00000137413 ENSMUSG00000023980 UniProt Q7Z7C8 Q9EQH4 RefSeq (mRNA) NM_138572 NM_022015 NM_001356290 RefSeq (protein) NP_612639 NP_071298 NP_001343219 Location (UCSC) Chr 6: 42.05 – 42.09 Mb Chr 17: 47.79 – 47.81 Mb PubMed search [3] [4]
Wikidata
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This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[5]